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Activated with the antibiotic rifampicin and a variety of plant metabolites, for example hyperforin, guggulipid, colupulone, and isoflavones. Response to unique ligands is species-precise. Activated by Obviously developing steroids, such as pregnenolone and progesterone. Binds to a response ingredient in the promoters in the CYP3A4 and ABCB1/MDR1 g